Screening with Xcellomics

Xcellomics offers a wide range of expertise in screens across a number of platforms as well as technical and scientific advice for the development and execution of your assays. The Xcellomics team is available for consultation at the earliest stages of assay conception and will work closely with each investigator through all stages of assay development, optimisation, automation and screening.

Cell-based Small Molecule Screens

These small molecule screens utilize cells plated in 96 or 384 well plates to produce visual and quantifiable phenotypic changes in the cells affecting pathways directly associated with disease states. Small compound cell-based screens ensure compound solubility, membrane permeability, low cellular toxicity and effectiveness at therapeutically-relevant concentrations.

For more information please visit the TDI’s website

Pooled CRISPR Screens

CRISPR/Cas9 technology is ideally suited for genome-wide screening applications due to the ease of generating guide RNAs (gRNAs) and the versatility of Cas9 to knockout expression of target genes. Pooled lentiviral CRISPR libraries are a heterogenous population of lentiviral transfer vectors, each containing an individual gRNA targeting a single gene in a given genome.

For more information please visit the TDI’s website

  • Lentivirus for all libraries are produced at the TDI for Xcellomics.

    Genome-wide CRISPR knockout and CRISPR activation and other libraries are available for Xcellomics.